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Spray drying lactose from organic solvent suspensions for aerosol delivery to the lungs

Wei-Ren Ke ᵃ , Rachel Yoon Kyung Chang ᵃ , Philip Chi Lip Kwok ᵃ , Donghao Chenᵇ, Hak-Kim Chan ᵃ

a. Advanced Drug Delivery Group, Sydney Pharmacy School, Faculty of Medicine and Health, Pharmacy and Bank Building A15, The University of Sydney, NSW 2006, Australia
b. Hangzhou Chance Pharmaceuticals, Hangzhou, China

Overcoming challenges for development of amorphous powders for inhalation: Expert Opinion on Drug Delivery

Rachel Yoon Kyung Chang, Lan Chen, Donghao Chen & Hak-Kim Chan

A new hypothesis to investigate bioequivalence of pharmaceutical inhalation products

Maryam Khoubnasabjafari, Elaheh Rahimpour, Morteza Samini, Vahid Jouyban-Gharamaleki, Lan Chen, Donghao Chen, Hak-Kim Chan & Abolghasem Jouyban

Does upper airway deformation affect drug deposition?

Shaokoon Chengᵃ, Agisilaos Kourmatzisᵇ, Taye Mekonnenᵃ, Hanieh Gholizadehᵃ, Joel Racoᵃ, Lan Chen ͨ , Patricia Tangᵈ, Hak-Kim Chanᵈ

a. Macquarie University, School of Engineering, Faculty of Science and Engineering Sydney, Australia
b. University of Sydney, School of Aerospace, Mechanical and Mechatronic Engineering, Sydney, Australia
c. Hangzhou Chance Pharmaceuticals, Hangzhou, China
d. University of Sydney, Sydney Pharmacy School, Advanced Drug Delivery Group, Sydney, Australia

Amorphous powders for inhalation drug delivery

Lan Chen ᵃ , Tomoyuki Okudaᵇ· ͨ, Xiang-Yun Lu ᵃ , Hak-Kim Chan ͨ

a. School of Medical Instrument and Food Engineering; University of Shanghai for Science and Technology; Shanghai 200093; China
b. Faculty of Pharmacy; Meijo University; 150 Yagotoyama, Tempaku-ku, Nagoya 468-8503; Japan
c. Advanced Drug Delivery Group; Faculty of Pharmacy; The University of Sydney; Sydney; 2006, NSW, Australia

Investigation of dry powder aerosolization mechanisms in different channel designs

Lan Chen ͣ ·ᵇ, Rui-Lin Heng ͣ, Mulugeta Admasu Delelebᵇ·ᶜ, Jian Cai ͣ, Di-Zheng Du ͩ, Umezuruike Linus Oparaᵇ

a. School of Medical Instrument and Food Engineering, University of Shanghai for Science and Technology, Shanghai 200093, China
b. Postharvest Technology Research Laboratory, South African Research Chair in Postharvest Technology, Stellenbosch University, Stellenbosch 7602, South Africa\
c. Department of Post-harvest Technology, Leibniz Institute of Agricultural Engineering (ATB) Potsdam-Bornim, Max-Eyth-Allee 100, Potsdam 14469, Germany
d. Shanghai Chenpon Pharmaceutical Technology Co., Ltd., Shanghai 201203, China

Large Porous Particles for Sustained Protection from Carbachol-Induced Bronchoconstriction in Guinea Pigs

Abdellaziz Ben-Jebria, Donghao Chen, Mary Lou Eskew, Rita Vanbever, Robert Langer & David A. Edwards

Dry powder pharmaceutical biologics for inhalation therapy

Rachel Yoon Kyung Chang ᵃ , Michael Y.T. Chow ᵃ , Dipesh Khanal ᵃ , Donghao Chenᵇ, Hak-Kim Chan ᵃ

a. Advanced Drug Delivery Group, Sydney Pharmacy School, Faculty of Medicine and Health, The University of Sydney, NSW 2006, Australia
b. Hangzhou Chance Pharmaceuticals, Hangzhou, China

Administration of dry powders during respiratory supports

Wei-Ren Ke¹, Rachel Yoon Kyung Chang¹, Philip Chi Lip Kwok , Patricia Tang¹, Lan Chen², Donghao Chen², and Hak-Kim Chan²

1. Advanced Drug Delivery Group, School of Pharmacy, Faculty of Medicine and Health, University of Sydney, Sydney, New South Wales, Australia;
2. Hangzhou Chance Pharmaceuticals, Hangzhou, China

Pulmonary drug delivery to older people

Martin Wallinᵃ·ᵇ, Tatsuaki Tagamiᵃ·ᶜ, Lan Chenᵈ, Mingshi Yangᵇ, Hak-Kim Chanᵃ

1. Advanced Drug Delivery Group, Faculty of Pharmacy, University of Sydney, NSW 2006, Australia; Department of Pharmacy, University of Copenhagen, Universitetsparken 2, DK-2100 Copenhagen, Denmark.
2. Advanced Drug Delivery Group, Faculty of Pharmacy, University of Sydney, NSW 2006, Australia; Drug Delivery and Nano Pharmaceutics, Graduate School of Pharmaceutical Sciences, Nagoya City University, 3-1 Tanabe-dori, Mizuho-ku, Nagoya 467-8603, Japan.
3. School of Medical Instruments and Food Engineering, University of Shanghai for Science and Technology, Shanghai 200093, China.
4. Department of Pharmacy, University of Copenhagen, Universitetsparken 2, DK-2100 Copenhagen, Denmark.
5. Advanced Drug Delivery Group, Faculty of Pharmacy, University of Sydney, NSW 2006, Australia. Electronic address: kim.chan@sydney.edu.au.

Prediction of Local Drug Exposure of Dry Powder Inhaler CXG87 (budesonide/formoterol) Using Physiologically-Based Pharmacokinetic Model

Yuran Cao¹²,Yuming Hu³,Jing Zhang²,Bo Liu⁴,Lan Chen⁵,Donghao Chen⁵,Meiqing Feng¹

1. School of Pharmacy, Fudan University, Shanghai, China.

2. Phase I Clinical Research Center, Huashan Hospital, Fudan University, Shanghai, China.

3. Yinghan Pharmaceutical Technology (Shanghai) Co., Ltd., Shanghai, China.

4. School of Chemistry and Chemical Engineering, Shanghai University of Engineering Science, Shanghai, China.

5. Hangzhou Changxi Pharmaceutical Co., Ltd., Zhejiang, China.